Metabolic Fate of a New Anti-ulcer Drug (+)-(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-1-phenanthrenecarboxylic Acid 6-Sodium Salt Pentahydrate (TA-2711). II. Distribution in the Rat Stomach.
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منابع مشابه
Effects of the new anti-ulcer drug ecabet sodium (TA-2711) on pepsin activity. I. Inactivation of enzyme protein.
To investigate the mechanism of the anti-peptic action of ecabet sodium (TA-2711) observed in pylorous-ligated rats, effects of this drug on the peptic activity of rat gastric juice, purified hog pepsin and pepsinogen were studied in vitro. After incubation with or without ecabet at acidic pH, the reaction mixture was centrifuged, and the peptic activity of the supernatant was measured. Ecabet ...
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In the title cocrystal, [Ni(C(11)H(10)N(3)O(2))(2)]·[Ni(NCS)(2)(C(11)H(11)N(3)O(2))(H(2)O)], both Ni(II) ions are in disorted octa-hedral coordination environments. One Ni(II) ion is coordinated by four N atoms and two O atoms from two tridentate 6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate (DPP) ligands, while the other Ni(II) ion is coordinated by a tridentate 6-((3,5-dimethyl-1H-pyrazol-1-yl))...
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In the title 1:1 adduct, C(11)H(10)ClN(3)O(2)·C(18)H(15)OP, the dihedral angle between the pyridine and pyrazole rings is 10.3 (2)°. The two components of the adduct are linked by an O-H⋯O hydrogen bond.
متن کامل1-(5-Hydroxy-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one
The title chromene, C(14)H(16)O(4), was isolated from the stems of Polyalthia plagioneura Diels. The mol-ecular structure is stabilized by an intra-molecular O-H⋯O hydrogen bond, which generates an S(6) ring. In the crystal, the mol-ecules are linked by C-H⋯O inter-actions, generating [010] chains.
متن کامل(E)-7-(Pyren-1-yl)hept-6-enoic acid
The title compound, C(23)H(20)O(2), is a precursor of a pyrene-based supra-molecular element for non-covalent attachment to a carbon nanotube. The asymmetric unit contains three independent mol-ecules. The carb-oxy-lic acid group in each of these mol-ecules serves as an inter-molecular hydrogen-bond donor and acceptor, generating the commonly observed double O-H⋯O hydrogen-bond motif in an eigh...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1991
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.14.547